MIMS Education

Clinical data and expert consensus on HCC surveillance with PIVKA-II assay

Clinical data and expert consensus on HCC surveillance with PIVKA-II assay

Gastroenterology And HepatologyOncologySurgery
A badge with ribbon in color black CME Unit: 0.5/1 pts | An analog clock in color black 1 hour | A black calendar with white triangle in center that has a black exclamation point in the middle 14 Jun 2024 


About this course

HCC surveillance of at-risk patients leads to early detection of HCC and improves overall survival rate. Currently, a combination of liver ultrasound and measurement of serum alpha fetoprotein (AFP) is the recommended strategy in HCC surveillance but the specificity and sensitivity of these modalities in detecting HCC remains suboptimal. Therefore, a new modality is required to improve the performance of HCC surveillance.

PIVKA-II is a potential screening biomarker for HCC. In this presentation, Professor Henry Chan presents an overview of the clinical utility of PIVKA-II in HCC surveillance and highlights experts’ recommendation on the use of this modality in Hong Kong.

Learning outcomes

Upon completion of this module, participants will be able to:
  • Identify risk factors that necessitate hepatocellular carcinoma (HCC) surveillance and the importance of early detection
  • Recognise the limitations of current strategies used in HCC surveillance
  • Understand the role of protein induced by vitamin K absence-II (PIVKA-II) in HCC diagnosis
  • Gain insights into an experts’ consensus on the use of PIVKA-II in the region

Topics covered

  • Overview of HCC surveillance
  • Limitations of current modalities used for HCC surveillance
  • Overview of PIVKA-II
  • Experts’ consensus on the clinical utility of PIVKA-II
  • Improving sensitivity for detection of HCC with PIVKA-II
  • PIVKA-II in HCC with tumour size ≤2 cm, alpha-fetoprotein-negative HCC, non-alcoholic fatty liver disease-HCC, and alcoholic liver disease-HCC

1 CME Point Available

  • This module is accredited for 1 CME Point for medical practitioners enrolled in The Medical Council of Hong Kong’s Continuing Medical Education Programme for Practising Doctors who are not taking CME for Specialists.
  • This module is accredited for 0.50 CME Point for fellows of the Hong Kong College of Physicians, Hong Kong College of Emergency Medicine, Hong Kong College of Community Medicine, The College of Surgeons of Hong Kong, and The Hong Kong College of Pathologists, and Hong Kong College of Radiologists.
  • Please note that this module will not earn CME credit for fellows of colleges not listed here.
  • A certificate can be downloaded upon successful completion of the quiz. Please use the information on the certificate to claim your CME points.