MIMS Education

When statins are not enough: PCSK9 inhibitors as an LDL-lowering agent

When statins are not enough: PCSK9 inhibitors as an LDL-lowering agent

CardiologyInternal MedicineFamily MedicineGeneral Practice
A badge with ribbon in color black CME Unit:0.5/1 Point | An analog clock in color black 1 hour | A black calendar with white triangle in center that has a black exclamation point in the middle 20 Apr 2024 


About this course

Proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9) is an enzyme that regulates low density lipoprotein (LDL) receptor degradation. The gene for PCSK9 is implicated in patients with familial hypercholesterolemia, and a gain-of-function mutation in that gene was found to be associated with high LDL-cholesterol (LDL-C) levels.

PCSK9 inhibitors are monoclonal antibodies that prevent the degradation of LDL receptors thereby decreasing LDL-C levels. This e-learning module discusses the biology behind PCSK9, the mechanism of PCSK9 inhibitors, and when to use PCSK9 inhibitors for lipid-lowering management.

Learning outcomes

Upon completion of the educational activity, participants should be able to:
  • Understand the role of PCSK9 in cholesterol metabolism and the mechanism of action of PCSK9 inhibitors
  • Review the data behind drugs acting on PCSK9
  • Enumerate the uses of PCSK9 inhibitors in current guidelines

Topics covered

  • Introduction
  • Biochemistry of PCSK9
  • Drugs acting on PCSK9
  • Review of Outcomes Trials of PCSK9 inhibitors & siRNA
  • Current recommendations for use of PCSK9 inhibitors & siRNA

Speaker for this course:

DR. Dick C.Y. Cheung

Specialist in Cardiology

Keywords: dyslipidemia, PCSK9, PCSK9 inhibitors, when to use PCSK9 inhibitors

1 CME Point Available

  • This module is accredited for 1 CME Point for medical practitioners enrolled in The Medical Council of Hong Kong’s Continuing Medical Education Programme for Practising Doctors who are not taking CME for Specialists.
    • This module is accredited for both Hong Kong Doctors Union (HKDU) members and non-members.
  • This module is accredited for 0.5 CME Point for fellows of the Hong Kong College of Physicians, Hong Kong College of Emergency Medicine, and Hong Kong College of Community Medicine.
  • Please note that this module will not earn CME credit for fellows of colleges not listed here.
  • A certificate can be downloaded upon successful completion of the quiz. Please use the information on the certificate to claim your CME points.