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Better Together: Using Combination Therapy in the Intensive Lowering of LDL-C in Dyslipidemia

Better Together: Using Combination Therapy in the Intensive Lowering of LDL-C in Dyslipidemia

CardiologyFamily MedicineGeneral PracticeInternal Medicine
A badge with ribbon in color black 1 point | An analog clock in color black 1 Hour | A black calendar with white triangle in center that has a black exclamation point in the middle 14 Jun 2025 
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Overview

About this course

Dyslipidemia management is vital for cardiovascular risk reduction as elevated lipid levels have been attributed as a major risk factor for ischemic heart disease deaths. Dyslipidemia management highlights the causal link between circulating low-density lipoprotein cholesterol (LDL C) levels, the duration of lipoprotein exposure, and the total atherosclerotic plaque burden in a patient. Consequently, it is essential for patients at very high cardiovascular risk to lower their cholesterol levels as early and as much as possible.

To meet the stringent lipid targets, guidelines recommend initiating combination therapy for very high-risk patients with elevated LDL-C levels who are unlikely to achieve these goals with statins alone. However, despite LDL-C level lowered to target, residual cardiovascular risk persists due to the presence of other lipoproteins and triglycerides, thus, must also be managed.

This module will cover the latest guidelines on lipid-lowering therapies aimed at reducing cardiovascular morbidity. It will specifically focus on the comprehensive use of combination therapy for dyslipidemia and strategies for clinicians to optimize these treatments to achieve therapeutic goals.

Learning outcomes

At the end of this learning module, participants should be able to:

  • Understand the role of low-density lipoprotein cholesterol (LDL-C), other lipoproteins, and triglycerides in the development of atherosclerotic cardiovascular disease (ASCVD).
  • Explore the current and future management of dyslipidemia with statins and non-statins.

Topics covered

  • The role of LDL-C in ASCVD
  • Goal of lipid-lowering therapy
  • Cardiovascular (CV) risk assessment and LDL-C treatment targets
  • ESC/EAS 2019 Dyslipidemia Management Algorithm
  • LDL-C lowering therapy
  • Beyond statin therapy
    • Limitations of statin monotherapy
    • Combination therapy
  • Residual CV risk
    • A review of the lipid profile
    • Triglyceride-rich lipoproteins (TGRL), remnants, lipoprotein(a), apoB lipoproteins
  • New Targets for Lipid-lowering Therapies
  • Possible Future Approach to Lipid-lowering
  • 2019/2021 ESC/EAS Treatment Goals for CVD Prevention
  • CV Risk Associated with Triglycerides (TG)
  • Triglyceride Management
    • Diet and Lifestyle Modifications
    • Pharmacotherapy
    • Omega-3 Fatty Acids
    • Summary of hypertriglyceridemia treatment recommendations

1 CME Point Available

  • Score at least 60% on the quiz.
  • A certificate can be downloaded upon successful completion. Please use the information on the certificate to claim your CPD points.

Keywords: dyslipidemia, hyperlipidemia, cholesterol, cholesterol management, LDL C, triglycerides, triglycerides management

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