About this course

Cardiac amyloidosis is life-threatening, infiltrative cardiomyopathy that commonly leads to heart failure but nonetheless may be overlooked as a cause.^1-6 The most common types of cardiac amyloidosis (>95%) include amyloid light-chain (AL) amyloidosis and transthyretin amyloid cardiomyopathy (ATTR-CM).^5,7 ATTR-CM may be subclassified, based on the presence or absence of a mutation in the transthyretin gene, into wild-type ATTR (wtATTR) or hereditary ATTR (hATTR).^5,8

This online course focuses on ATTR-CM, reviewing the burden associated with this disease and exploring the “red flags” and combinations of clinical features that should raise suspicion for ATTR-CM. The diagnostic algorithm for ATTR-CM is also explored, highlighting the non-invasive criteria that are accepted for this form of cardiac amyloidosis.⁹

Learning objectives

• Be aware of the disease burden associated with ATTR-CM.
• Recognise the “red flag” signs and symptoms of ATTR-CM, in particular that LV hypertrophy is a key red flag of ATTR-CM, and the combination of LV hypertrophy and another red flag warrants suspicion of ATTR-CM.⁹
• Understand the pathway to diagnosis of ATTR-CM and be aware that ATTR-CM is the only form of cardiac amyloidosis that can be diagnosed via non-invasive means.⁹

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